| Rank | Time | Student | Grade | School | Year | |
| 1 | 17:12.70 |
Natalie Barnard
Lafayette (Wildwood) | 2023
| Sr | Lafayette (Wildwood) | 2023 | Class 5 |
| 2 | 17:14.22 |
Taylor Werner
Ste. Genevieve | 2015
| Sr | Ste. Genevieve | 2015 | Class 3 |
| 3 | 17:31.30 |
Taylor Werner
Ste. Genevieve | 2013
| So | Ste. Genevieve | 2013 | Class 3 |
| 4 | 17:37.29 |
Elyse Wilmes
Father Tolton Regional Catholic | 2023
| Jr | Father Tolton Regional Catholic | 2023 | Class 5 |
| 5 | 17:38.29 |
Hannah Long
Eureka | 2014
| Sr | Eureka | 2014 | Class 3 |